What is the pathological grade for a low-grade urothelial carcinoma post-TURBT when it later shows high grade?

In the context of the question regarding the pathological grading of urothelial carcinoma following a transurethral resection of bladder tumor (TURBT), it is essential to understand that a tumor’s grade can potentially change, particularly when the initial assessment shows low-grade characteristics, but subsequent biopsies or reviews reveal high-grade features.

When classifying tumors, "GX" signifies "grade cannot be assessed," which can be appropriate in scenarios where the initial grading is not definitive or when there are changes in tumor characteristics over time due to disease progression or treatment effects. In this case, if the urothelial carcinoma was initially reported as low-grade but then demonstrated high-grade features later on, it suggests an update may be necessary to reassess the tumor characteristics completely.

Assigning a grade based solely on prior information without factoring in the most recent findings would not accurately represent the tumor's current pathology. Therefore, "GX" is a suitable classification in this scenario, reflecting uncertainty about the pathological assessment due to changing tumor characteristics.

In summary, "GX" is correct as it indicates that the grade is not definitively assessable in light of the high-grade findings following an initial assessment suggesting low-grade characteristics. This context is vital for accurate tumor grading