Which condition is NOT associated with skin issues?

Acromegaly is a hormonal disorder that results from excess growth hormone, typically due to a benign tumor on the pituitary gland. While acromegaly can lead to noticeable changes in physical appearance, such as enlarged hands, feet, and facial features, it is not primarily characterized by issues affecting the skin in the same way that the other conditions are.

In contrast, psoriasis is a chronic autoimmune condition that primarily affects the skin, causing red, scaly patches. Hirsutism, which involves excessive hair growth in women in areas where men typically grow hair, is also associated with hormonal imbalances that notably affect skin appearance. Alopecia, characterized by hair loss, results in skin conditions where hair follicles are affected.

Therefore, among the options provided, acromegaly stands out as the condition least associated with skin issues directly, making it the correct selection in this context.