Which grade category would you assign to a sample that cannot be assessed and is therefore unknown?

In oncological grading, a sample that cannot be assessed for differentiation or cannot be classified into any of the specific grades is assigned a category indicating that the grading is unknown. This is represented by the designation "GX."

Choosing "GX" clearly communicates to healthcare providers and researchers that the sample does not have sufficient information to determine its grade and therefore its behavior and potential treatment options remain uncertain. This designation is critical in documenting cases where the tumor characteristics cannot be established, either due to inadequate pathological material or other limitations in the assessment process. Accurate coding of this unknown category is vital for maintaining clarity in clinical records and for making informed treatment decisions in the absence of definitive information.